A high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKC α activation

CAR T cell therapy is a promising approach to improve outcomes and decrease toxicities for patients with cancer. While extraordinary success has been achieved using CAR T cells to treat patients with CD19-posi...

Source: Journal of Experimental and Clinical Cancer Research - April 1, 2024 Category: Cancer & Oncology Authors: Ha Won Lee, Carla O ’Reilly, Alex N. Beckett, Duane G. Currier, Taosheng Chen and Christopher DeRenzo Tags: Research Source Type: research