Cancers, Vol. 16, Pages 1395: Clinical Relevance of Physical Function Outcomes in Cancer Cachexia

Cancers, Vol. 16, Pages 1395: Clinical Relevance of Physical Function Outcomes in Cancer Cachexia Cancers doi: 10.3390/cancers16071395 Authors: Lucas Caeiro Sofia Jaramillo Quiroz Jenna S. Hegarty Ellen Grewe Jose M. Garcia Lindsey J. Anderson Managing clinical manifestations of cancer/treatment burden on functional status and quality of life remains paramount across the cancer trajectory, particularly for patients with cachexia who display reduced functional capacity. However, clinically relevant criteria for classifying functional impairment at a single point in time or for classifying meaningful functional changes subsequent to disease and/or treatment progression are lacking. This unmet clinical need remains a major obstacle to the development of therapies for cancer cachexia. This review aims to describe current literature-based evidence for clinically meaningful criteria for (1) functional impairment at a single timepoint between cancer patients with or without cachexia and (2) changes in physical function over time across interventional studies conducted in patients with cancer cachexia. The most common functional assessment in cross-sectional and interventional studies was hand grip strength (HGS). We observed suggestive evidence that an HGS deficit between 3 and 6 kg in cancer cachexia may display clinical relevance. In interventional studies, we observed that long-duration multimodal therapies with a focus on skeletal muscle may benefit HGS in pati...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research