The design, synthesis and bioactivity evaluation of novel androgen receptor degraders based on hydrophobic tagging

In conclusion, the present study lays the foundation for the development of a completely new class of therapeutic agents for the treatment of mCRPC, and further design and synthesis of AR-targeting degraders are currently in progress for better degradation rate.PMID:38537338 | DOI:10.1016/j.bioorg.2024.107309

Source: Bioorganic Chemistry - March 27, 2024 Category: Chemistry Authors: Ying Sun Huating Wang Yaru Li Zhaoxiang Li Zhihui Mao Mengyao Zhang Yixian Shao Jiaqi Ye Dan Li Lihong Shan Source Type: research