The Syntheses of Chromium Aluminum Carbide (Cr < sub > 2 < /sub > AlC) MAX  Phase and Cr < sub > 2 < /sub > CTx MXene and Investigation of Their Antimicrobial Properties

Appl Biochem Biotechnol. 2024 Mar 28. doi: 10.1007/s12010-024-04910-w. Online ahead of print.ABSTRACTChromium aluminum carbide (Cr2AlC) MAX phase and Cr2CTx (MXene-Cr) were synthesized by the pressureless sintering method and hydrothermal method, respectively. In addition to this, the free radical scavenging activities (FRSA) of MAX-Cr phase and MXene-Cr compounds were tested and compared with ascorbic acid and trolox as standard compounds. The obtained FRSA results of MAX-Cr phase and MXene-Cr were 42.82 and 59.64%, respectively, at 100 mg/L concentration. MXene-Cr showed a 66.90% inhibitory effect on α-amylase at 200 mg/L. The DNA nuclease activity of compounds was determined to be extremely satisfactory at 50, 100, and 200 mg/L concentrations. Moreover, the prepared MAX-Cr phase and MXene-Cr were investigated for antimicrobial activity against six bacterial and two fungal strains by the broth microdilution method. Compounds provided more significant inhibition against Gram-positive bacteria than Gram-negative bacteria and fungi. MAX-Cr phase and MXene-Cr almost completely inhibited microbial cell viability at a 25 mg/L concentration. Additionally, MXene-Cr showed 89.86% and 87.01% antibiofilm activity against S. aureus and P. aeruginosa, respectively, while the antibiofilm activity of the MAX-Cr phase was over 90%.PMID:38538871 | DOI:10.1007/s12010-024-04910-w
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Source Type: research