Familial rare EGFR-mutant lung cancer syndrome: Review of literature and description of R776H family

Interest in hereditary lung cancer is increasing, in particular germline mutations in the Epidermal Growth Factor Receptor (EGFR) gene. We review the current literature on this topic, discuss risk of developing lung cancer, treatment and screening options and describe a family of 3 sisters with lung cancer and their unaffected mother all with a rare EGFR germline mutation (EGFR p.R776H).

Source: Lung Cancer - March 29, 2024 Category: Cancer & Oncology Authors: L. Gabriel, T. McVeigh, S. Macmahon, Z. Avila, L. Donovan, I. Hunt, A. Draper, A. Minchom, S. Popat, M. Davidson, J. Bhosle, C. Milner Watts, M. Hubank, L. Yuan, MER O'Brien Source Type: research