New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682

Chem Biodivers. 2024 Mar 27:e202400584. doi: 10.1002/cbdv.202400584. Online ahead of print.ABSTRACTTwo pairs of new enantiomeric hydroxyphenylacetic acid derivatives, (±)-corylophenols A and B ((±)-1 and (±)-2), a new α-pyrone analogue, corylopyrone A (3), and six andrastin-type meroterpenoids (4-9) were isolated and identified from the deep-sea cold-seep sediment-derived fungus Penicillium corylophilum CS-682. Their structures and stereo configurations were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis, J-based configuration analysis, and quantum chemical calculations of ECD, specific rotation, and NMR (with DP4+ probability analysis). Compound 3 showed inhibitory activity against some strains of pathogenic bacteria.PMID:38544421 | DOI:10.1002/cbdv.202400584

Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Chi-Sheng Zhu Xiao-Ming Li Sui-Qun Yang Yi-Wei Liu Bin-Gui Wang Xin Li Source Type: research