Limitations in membrane protein structure determination by lipid nanodiscs

Trends Biochem Sci. 2024 Mar 26:S0968-0004(24)00076-8. doi: 10.1016/j.tibs.2024.03.010. Online ahead of print.ABSTRACTLipid nanodiscs are popular mimetics of biological membranes for determining membrane protein structures. However, a recent study revealed that the choice of nanodisc scaffold directly influenced the structure of an ion channel. This finding prompts us to be cautious and calls for improved membrane mimetics for structure determination.PMID:38538407 | DOI:10.1016/j.tibs.2024.03.010

Source: Trends in Biochemical Sciences - March 27, 2024 Category: Biochemistry Authors: Chen Zhao Source Type: research