Trichothecenes with cytotoxic activity and benzene derivatives with hypolipidemic activity from < em > trichothecium < /em > sp

Nat Prod Res. 2024 Mar 27:1-7. doi: 10.1080/14786419.2024.2332488. Online ahead of print.ABSTRACTFive trichothecenes including a new one, together with two previously undescribed benzene derivatives were isolated from the solid culture of Trichothecium sp. Their structures were established by 1D and 2D NMR data in conjunction with HR-ESI-MS analysis. Compounds 1-5 exhibited cytotoxicity against MCF-7 cell lines at various levels ranging from IC50 of 7.23 to 16.95 μM. Compound 6 decreased the concentration of blood lipids in zebra fish at the concentration of 20 μM.PMID:38534130 | DOI:10.1080/14786419.2024.2332488

Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: An-An Yang Yi-Fan Guo Ke-Ran Hao Yi-Ting Wu Liang Xing Source Type: research