Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF

Nature, Published online: 27 March 2024; doi:10.1038/s41586-024-07250-1DCAF5 has a quality-control function for SWI/SNF complexes and promotes the degradation of incompletely assembled SWI/SNF complexes in the absence of SMARCB1.

Source: Nature AOP - March 27, 2024 Category: Research Authors: Sandi Radko-Juettner Hong Yue Jacquelyn A. Myers Raymond D. Carter Alexis N. Robertson Priya Mittal Zhexin Zhu Baranda S. Hansen Katherine A. Donovan Moritz Hunkeler Wojciech Rosikiewicz Zhiping Wu Meghan G. McReynolds Shourya S. Roy Burman Anna M. Schmok Source Type: research