Unlocking the Pancreatic Cancer Puzzle: Using Intermediate Cells to Target Treatment

Clin Cancer Res. 2024 Mar 26. doi: 10.1158/1078-0432.CCR-23-3295. Online ahead of print.ABSTRACTKRT17-high intermediate cell population with elevated CXCL8 expression informed elevated myeloid infiltration status in tumors and associated with pro-tumorigenic signatures in peripheral granulocytes from pancreatic cancer patients. Further, CXCL8 plasma levels were found to resemble KRT17+/CXCL8+ abundance in tumors, in which higher levels predicted worse patient outcomes.PMID:38530840 | DOI:10.1158/1078-0432.CCR-23-3295
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research