Conformational fingerprinting with Raman spectroscopy reveals protein structure as a translational biomarker of muscle pathology

This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.James J. P. Alix, Maria Plesia, Alexander P. Dudgeon, Catherine A. Kendall, Channa Hewamadduma, Marios Hadjivassiliou, Gr áinne S. Gorman, Robert W. Taylor, Christopher J. McDermott, Pamela J. Shaw, Richard J. Mead, John C. Day Using a combination of peak fitting and matrix factorisation techniques we show that neuromuscular disease in both human biopsies and preclinical models manifests alterations in protein secondary structure. Created with biorender.com. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research