Commentary on: ‘Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis?’ by Dvir-Ginzberg et al.

The commentary by Dvir-Ginzberg et al. challenges the field to improve rigor by evaluating OA mechanisms and therapeutic interventions in both male and female mice. The authors use the lens of senescence to evaluate how the preferential use of male mice has possibly skewed the current understanding of OA. Much like sex, age is a biological variable with a striking mismatch between clinical reality and preclinical models. There is a sharp increase in OA incidence after the age of 501, and yet most studies use joint injury in young mice to initiate consistent OA, with a defined window for intervention.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research