Radical cascade silylation/cyclization of 1,7-dienes to access silyl-substituted benzo[ < em > b < /em > ]azepin-2-ones

Chem Commun (Camb). 2024 Mar 25. doi: 10.1039/d4cc00499j. Online ahead of print.ABSTRACTA novel silyl radical-induced cascade silylation/cyclization of 1,7-dienes has been realized employing readily available hydrosilanes as a silicon source and Cu(I) salt as a catalyst. This protocol introduces diverse silicon fragments into a challenging 7-membered ring structure and provides an efficient approach to a wide array of biologically important silyl-substituted benzo[b]azepin-2-ones. Several control experiments suggest that the reaction undergoes a free radical process. The gram-scale synthesis and late-stage transformations further demonstrate the scalability and applicability of the reaction in organic synthesis.PMID:38523529 | DOI:10.1039/d4cc00499j

Source: Chemical Communications - March 25, 2024 Category: Chemistry Authors: Zhen Zhang Lichao Lu Guiling Li Xiaoyu Sheng Yijia Zhang Lin Yang Jiaqi Zhao Lei Xie Jiazhu Li Kai Sun Source Type: research