Parvalbumin neurons in the nucleus accumbens shell modulate seizure in temporal lobe epilepsy

In this study, we induced a spontaneous TLE model by intrahippocampal administration of kainic acid (KA), which generally induce acute seizures in first 2 h (acute phase) and then lead to spontaneous recurrent seizures after two months (chronic phase). We found that chemogenetic activation of NAc shell PV neurons could alleviate TLE seizures by reducing the number and period of focal seizures (FSs) and secondary generalized seizures (sGSs), while selective inhibition of PV exacerbated seizure activity. Ruby-virus mapping results identified that the hippocampus (ventral and dorsal) is one of the projection targets of NAc shell PV neurons. Chemogenetic activation of the NAc-Hip PV projection fibers can mitigate seizures while inhibition has no effect on seizure ictogenesis. In summary, our findings reveal that PV neurons in the NAc shell could modulate the seizures in TLE via a long-range NAc-Hip circuit. All of these results enriched the investigation between NAc and epilepsy, offering new targets for future epileptogenesis research and precision therapy.PMID:38522590 | DOI:10.1016/j.nbd.2024.106482

Source: Neurobiology of Disease - March 24, 2024 Category: Neurology Authors: Tong Jiang Shuyu Liang Xiaohan Zhang Shasha Dong HaiFang Zhu Ying Wang Yanping Sun Source Type: research