Utilizing medical thoracoscopy for the diagnosis of myelomatous pleural effusion: 2 case reports

We present two patients with biopsy proven myelomatous pleural effusion diagnosed via medical thoracoscopy (MT) followed by early commencement of myeloma specific chemotherapy which led to clinical, biochemical, and radiological resolution of the disease. AbstractMultiple myeloma (MM) is characterized by neoplastic proliferation of monoclonal antibody producing plasma cells. In clinical practice, pleural effusion is seen in up to 6% of MM patients, with many causative factors. Nevertheless, true myelomatous pleural effusion, defined as infiltration of the pleura by myeloma cells, is very rare. In this case report, we present two patients with biopsy proven myelomatous pleural effusion. The first patient developed myelomatous pleural effusion as initial presentation while the second patient's pleural effusion occurred during disease relapse. In both cases, prompt diagnosis via medical thoracoscopy (MT) followed by early commencement of myeloma specific chemotherapy led to clinical, biochemical, and radiological resolution and therefore were crucial steps in the management of myelomatous pleural effusion.

Source: Respirology Case Reports - March 25, 2024 Category: Respiratory Medicine Authors: Khai Lip Ng, Sin Nee Tan, Nai ‐Chien Huan, Mona Zaria Nasaruddin, Noriah Othman, Jamalul Azizi Abdul Rahaman Tags: CASE REPORT Source Type: research