The interplay of inflammation and placenta in maternal diabetes: insights into Hofbauer cell expression patterns

ConclusionThe expression profiles of IL-1β, CYP epoxygenases and sEH significantlly differ between controls and diabetic placentas and between T1DM and GDM. These facts suggest an association of the CYP epoxygenase-EETs-sEH axis with IL-1β expression as well as villous stromal hypovascularisation. Given the stable high expression of IL-10 in both controls and both types of diabetes, it appears that immune tolerance is maintained in HBCs.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research