Development of a multivariate prediction model for antidepressant resistant depression using reward-related predictors

DiscussionNon-responders displayed 3 distinct symptom profiles along internalizing dimensions of anxiety, anhedonia, motivation, and cognitive function. Results should be replicated in a prospective cohort sample for predictive validity; however, this study demonstrates validity for using a limited anhedonia and internalizing self-report instrument for distinguishing between antidepressant resistant and responsive depression profiles.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research