Synthesis of shape-programmable elastomer for a bioresorbable, wireless nerve stimulator

Biosens Bioelectron. 2024 Mar 16;254:116222. doi: 10.1016/j.bios.2024.116222. Online ahead of print.ABSTRACTMaterials that have the ability to manipulate shapes in response to stimuli such as heat, light, humidity and magnetism offer a means for versatile, sophisticated functions in soft robotics or biomedical implants, while such a reactive transformation has certain drawbacks including high operating temperatures, inherent rigidity and biological hazard. Herein, we introduce biodegradable, self-adhesive, shape-transformable poly (L-lactide-co-ε-caprolactone) (BSS-PLCL) that can be triggered via thermal stimulation near physiological temperature (∼38 °C). Chemical inspections confirm the fundamental properties of the synthetic materials in diverse aspects, and study on mechanical and biochemical characteristics validates exceptional stretchability up to 800 % and tunable dissolution behaviors under biological conditions. The integration of the functional polymer with a bioresorbable electronic system highlights potential for a wide range of biomedical applications.PMID:38518560 | DOI:10.1016/j.bios.2024.116222
Source: Biosensors and Bioelectronics - Category: Biotechnology Authors: Source Type: research