Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis

Metabolic processes are intricately linked to the resolution of innate inflammation and tissue repair, two critical steps for treating post-traumatic osteoarthritis (PTOA). Based on lipolytic and immunoregulatory actions of norepinephrine, we hypothesized that intra-articular β-adrenergic receptor (βAR) stimulation would suppress PTOA-associated inflammation in the infrapatellar fat pad (IFP) and synovium.

Source: Osteoarthritis and Cartilage - March 23, 2024 Category: Rheumatology Authors: Ravi K. Komaravolu, Padmaja Mehta-D ’souza, Taylor Conner, Madeline Allen, Jessica Lumry, Albert Batushansky, Nathan P. Pezant, Courtney G. Montgomery, Timothy M. Griffin Source Type: research