Canadian COVID-19 host genetics cohort replicates known severity associations

by Elika Garg, Paola Arguello-Pascualli, Olga Vishnyakova, Anat R. Halevy, Samantha Yoo, Jennifer D. Brooks, Shelley B. Bull, France Gagnon, Celia M. T. Greenwood, Rayjean J. Hung, Jerald F. Lawless, Jordan Lerner-Ellis, Jessica K. Dennis, Rohan J. S. Abraham, Jean-Michel Garant, Bhooma Thiruvahindrapuram, Steven J. M. Jones, CGEn HostSeq Initiative , Lisa J. Strug, Andrew D. Paterson, Lei Sun, Lloyd T. Elliott The HostSeq initiative recruited 10,059 Canadians infected with SARS-CoV-2 between March 2020 and March 2023, obtained clinical information on their disease experience and whole genome sequenced (WGS) their DNA. We analyzed the WGS data for genetic contributors to severe COVID-19 (considering 3,499 hospitalized cases and 4,975 non-hospitalized after quality control). We investigated the evidence for replication of loci reported by the International Host Genetics Initiative (HGI); analyzed the X chromosome; conducted rare variant gene-based analysis and polygenic risk score testing. Population stratification was adjusted for using meta-analysis across ancestry groups. We replicated two loci identified by the HGI for COVID-19 severity: theLZTFL1/SLC6A20 locus on chromosome 3 and theFOXP4 locus on chromosome 6 (the latter with a variant significant at P
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research