Alliaxylines A –E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss

AbstractA total of five new mexicanolides (1–5), namely alliaxylines A –E, together with two known limonoids6 and7, were isolated and identified fromDysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI –MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound2 was the most potent against the two tested cells, with IC50 values of 34.95  ± 0.21 and 44.39 ± 1.03 µM.Graphical Abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research