Sparsentan ameliorates glomerular hypercellularity and inflammatory-gene networks induced by IgA1-IgG immune complexes in a mouse model of IgA nephropathy

In conclusion, our data indicate that in the mouse model of IgAN, sparsentan targets immune and inflammatory processes leading to protection from mesangial hypercellularity.PMID:38511222 | DOI:10.1152/ajprenal.00253.2023

Source: Am J Physiol Renal P... - March 21, 2024 Category: Urology & Nephrology Authors: Colin Reily Zina Moldoveanu Tiziano Pramparo Stacy Hall Zhi-Qiang Huang Terri Rice Lea Novak Radko Komers Celia P Jenkinson Jan Novak Source Type: research