Phosphamide nucleotide analog: A substrate for polymerase synthesis of DNA

Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00089G, CommunicationJiong Meng, Qiaqia Guo, Xiaona Zhai, Song Yang, Shuai Wang, Pengcheng Wang, Debin Ji A type of modified nucleotide, deoxynucleotide γ-amidotriphosphates (dNTPγNH2s), exhibited around five times higher stability than that of dNTPs. These phosphamide nucleotides can be utilized by several DNA polymerases, and the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research