Oligonucleotide library screening for identification of virus-specific T-cell receptors

Eur J Immunol. 2024 Mar 19:e2350908. doi: 10.1002/eji.202350908. Online ahead of print.ABSTRACTWe demonstrate an optimized oligonucleotide library-based approach for the identification of virus-reactive T-cell receptors using Epstein-Barr virus as an example. HEK293T served as antigen-presenting cells and were co-cultured with human T cells that were transduced with T-cell receptors in question. T-cell activation was detected by CD137 expression.PMID:38501894 | DOI:10.1002/eji.202350908

Source: European Journal of Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Marthe-Lina Welters Serena Stadler Vasiliki Anastasopoulou Lars Bullinger Matthias Leisegang Thomas Kammert öns Carlotta Welters Leo Hansmann Source Type: research