Covid-19 in cystic fibrosis patients compared to the general population: Severity and virus-host cell interactions

Cystic fibrosis (CF), the most frequent autosomal recessive disease in the Caucasian population, is caused by mutations that disrupt chloride (Cl −) and bicarbonate transport by CFTR protein, a plasma membrane channel mainly expressed in epithelial cells of respiratory and gastrointestinal systems [1,2]. Most people with CF (pwCF) are affected by chronic obstructive pulmonary disease that is the result of the vicious cycle of respiratory ba cterial infection, mucus hypersecretion, and inflammation.

Source: Journal of Cystic Fibrosis - March 21, 2024 Category: Respiratory Medicine Authors: Fabiana Ciciriello, Francesco Panariello, Paola Medino, Arianna Biffi, Federico Alghisi, Chiara Rosazza, Patrizia Annunziata, Valentina Bouch è, Antonio Grimaldi, Daniela Guidone, Arianna Venturini, Gianfranco Alicandro, Massimo Oggioni, Pellegrino Cerin Tags: Original Article Source Type: research