Stereoselective synthesis of the Gal- α-(1→3)-Gal-β-(1→3)-GlcNAc trisaccharide: a new ligand for DCAR and Mincle C-type lectin receptors

Chembiochem. 2024 Mar 20:e202400026. doi: 10.1002/cbic.202400026. Online ahead of print.ABSTRACTIn this work, we have discovered that the Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc trisaccharide, a fragment of the B antigen Type-1, is a new ligand of two C-type lectin receptors (CLRs) i.e. DCAR and Mincle which are key players in different types of autoimmune diseases. Accordingly, we report here on a straightforward methodology to access pure Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc trisaccharide. A spacer with a terminal primary amine group was included to the reducing end of the GlcNAc residue thus ensuring the further functionalization of the trisaccharide Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc.PMID:38506247 | DOI:10.1002/cbic.202400026

Source: Chembiochem - March 20, 2024 Category: Biochemistry Authors: Jacopo Tricomi Mike Aoun Bingze Xu Rikard Holmdahl Barbara Richichi Source Type: research