Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis

Nature, Published online: 20 March 2024; doi:10.1038/s41586-024-07206-5In Mycobacterium tuberculosis, the fitness cost of rifampicin resistance is partially due to excessive RNA polymerase pausing and is rescued by mutations in the pro-pausing transcription factor NusG.

Source: Nature AOP - March 20, 2024 Category: Research Authors: Kathryn A. Eckartt Madeleine Delbeau Vanisha Munsamy-Govender Michael A. DeJesus Zachary A. Azadian Abhijna K. Reddy Joshua Chandanani Nicholas C. Poulton Stefany Qui ñones-Garcia Barbara Bosch Robert Landick Elizabeth A. Campbell Jeremy M. Rock Source Type: research