Identification of dynamic microbiota signatures in patients with melanoma receiving ICIs: opportunities and challenges

Nature Reviews Clinical Oncology, Published online: 20 March 2024; doi:10.1038/s41571-024-00882-2The composition of the gut microbiota has emerged as a tumour-extrinsic factor that modulates response to immune-checkpoint inhibitors (ICIs), although the lack of consistency in microbiota signatures across studies has limited their value as reliable biomarkers. Herein, we discuss a recent study in which longitudinal microbiome profiling identified several taxa that are persistently enriched in patients with melanoma and a favourable response to ICIs.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research