Chemical Composition of  Artemisia Scoparia and Their Bioactivities

Chem Biodivers. 2024 Mar 18:e202400414. doi: 10.1002/cbdv.202400414. Online ahead of print.ABSTRACTThree undescribed sesquiterpenes (1-3), two enantiomeric pairs of monoterpenes (4a/4b-5a/5b), one alkyne (6), two known alkynes (7-8) and eight known coumarins (9-16) were isolated from the aerial parts extracts of Artemisia scoparia. The structures of these compounds were fully elucidated by their 1D and 2D NMR, HRESIMS spectral data analyses, and comparison with literature. The absolute configurations of compounds were determined by single-crystal X-ray crystallography (1), a comparison of experimental and calculated electronic circular dichroism (ECD) data (2-6). 15 showed moderate inhibitory activity with the NO release in LPS-induced RAW264.7 cells. 9-16 showed varying degrees of promoting melanogenesis and tyrosinase activity in B16 cells.PMID:38500337 | DOI:10.1002/cbdv.202400414

Source: Chemistry and Biodiversity - March 19, 2024 Category: Biochemistry Authors: Guziliayi Kuerban Ablajan Turak Nurmirza Boymirzayevich Begmatov Jiangyu Zhao Haji Akber Aisa Source Type: research