Algorithm Training and Testing for a Non-Endoscopic Barrett ’s Esophagus Detection Test in Prospective Multicenter Cohorts
Endoscopic Barrett ’s esophagus (BE) and esophageal adenocarcinoma (EAC) detection is invasive and expensive. Non-endoscopic BE/EAC detection tools are guideline-endorsed alternatives. We previously described a 5-methylated DNA marker (MDM) panel assayed on encapsulated sponge cell collection device (CCD) specimens. We aimed to train a new algorithm using a 3-MDM panel and test its performance in an independent cohort.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Prasad G. Iyer, Seth W. Slettedahl, Douglas W. Mahoney, Maria Giakoumopoulos, Marilyn C. Olson, Martin Krockenberger, William R. Taylor, Patrick Foote, Calise Berger, Cadman Leggett, T.T. Wu, Eduardo Antpack, Gary W. Falk, Gregory G. Ginsberg, Julian A. A Source Type: research
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