The truth about the lower plasma concentration of the (-)-isomer after racemic doxazosin administration in rats: Stereoselective inhibition of the (-)-isomer by the (+)-isomer at CYP3A.

In conclusion, although (-)-DOX is not depleted faster than (+)-DOX when only a single isomer of DOX is incubated with rat liver microsomes, it is depleted much faster than (+)-DOX when a mixture of the two isomers was used, suggesting a prominent and stereoselective inhibition of the (-)-isomer over the (+)-isomer at the CYP3A enzyme. PMID: 26116989 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26116989?dopt=Abstract

Source: European Journal of Pharmaceutical Sciences - June 25, 2015 Category: Drugs & Pharmacology Authors: Kong D, Li Q, Zhang P, Zhang W, Zhen Y, Ren L Tags: Eur J Pharm Sci Source Type: research