Expression of TLR2, IL-1 β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians

The expression of the gene of pattern recognition receptor TLR2, proinflammatory cytokine IL-1 β, and anti-inflammatory cytokine IL-10 was analyzed in the peripheral blood of nonagenarians (n=219; mean age 92.1 years, 77 men and 142 women) in comparison with healthy young donors (n=24; mean age 22.5 years, 16 women and 8 men). Nonagenarians were interviewed, medical records were analyzed, and a comprehensive geriatric assessment was performed according to the Clinical Guidelines on Frailty. The level of gene expression was determined by real-time PCR. The participation of inflammatory mechanisms in the immunosenescence was revealed. It was shown that increased expression ofIL1B andTLR2 genes is associated with the development of frailty in nonagenarians and can be a factor of pathological aging. Increased expression ofIL10 gene can be considered as a factor of successful aging in nonagenarians.

Source: Bulletin of Experimental Biology and Medicine - March 16, 2024 Category: Biology Source Type: research