Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11 β-Prostaglandin F2α

CONCLUSIONS: Incorporating DMS devices greatly improved the specificity of BPG measurements by LC-MS/MS, as evidenced by the comparison of chromatograms and fragment ion results. Validation studies showed exceptional performance for established analytical metrics, indicating that this technology can be used to minimize the impact of interferences without adversely impacting other aspects of analytical or clinical performance.PMID:38462204 | DOI:10.1016/j.clinbiochem.2024.110745

Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Kayla Moehnke Jennifer Kemp Michelle R Campbell Ravinder J Singh Anne E Tebo Anthony Maus Source Type: research