Conquering homocystinuria with engineered probiotics

Cell Host Microbe. 2024 Mar 13;32(3):298-300. doi: 10.1016/j.chom.2024.02.008.ABSTRACTPyridoxine-unresponsive homocystinuria has lifelong implications for health. In this issue, Perreault and colleagues present evidence that orally delivered engineered probiotic Escherichia Coli Nissle SYNB1353 is a promising candidate in reducing homocysteine, with successful trials in mice, monkeys, and humans. However, further probiotic optimization and safety assessments are required.PMID:38484708 | DOI:10.1016/j.chom.2024.02.008
Source: Cell Host and Microbe - Category: Microbiology Authors: Source Type: research