Single-cell DNA sequencing reveals a high incidence of chromosomal abnormalities in human blastocysts

In conclusion, our findings indicated that mosaicism was prevalent in good-quality blastocysts, whereas these blastocysts would likely be identified as normal with current bulk DNA-Seq techniques used for preimplantation genetic testing for aneuploidy.

Source: Journal of Clinical Investigation - March 16, 2024 Category: Biomedical Science Authors: Effrosyni A. Chavli, Sjoerd J. Klaasen, Diane Van Opstal, Joop S.E. Laven, Geert J.P.L. Kops, Esther B. Baart Source Type: research