Upregulation of shelterin and CST genes and longer telomeres are associated with unfavorable prognostic characteristics in prostate cancer.

Prostate cancer (PC) is one of the most diagnosed cancers in men and is a severe public health problem worldwide [1,2]. A peculiar feature of PC is the fact of its immense heterogeneity and genetic instability, which makes it challenging to classify into well-defined molecular subtypes [3]. In practical terms, because of this heterogeneity, classical prognostic factors, such as serum PSA and ISUP score, are not accurate enough to distinguish aggressive from indolent tumors early [4 –7]. Added to this, we know that damage caused by excessive treatment and diagnosis is a real problem in PC since while the vast majority of localized cancers have indolent behavior, a small subset of tumors are highly aggressive, with a high morbidity and lethality rate [8].

Source: Cancer Genetics and Cytogenetics - March 15, 2024 Category: Genetics & Stem Cells Authors: Gabriel Arantes dos Santos, Nayara I Viana, Ruan Pimenta, Juliana Alves de Camargo, Vanessa R Guimaraes, Poliana Rom ão, Patrícia Candido, Vinicius Genuino dos Santos, Vitória Ghazarian, Sabrina T Reis, Katia Ramos Moreira Leite, Miguel Srougi Source Type: research