Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii

Mol Biol (Mosk). 2023 Nov-Dec;57(6):1085-1097.ABSTRACTδ-Aminolevulinic acid dehydratase (ALAD) is a key enzyme of the cytoplasmic heme biosynthesis pathway. The primary structure of the ALAD gene, the multimeric structure of the ALAD/hemB protein, and ALAD expression during the annual reproductive cycle were studied in the cold-water marine sponge Halisarca dujardinii. The results implicated the GATA-1 transcription factor and DNA methylation in regulating ALAD expression. Re-aggregation of sponge cells was accompanied by a decrease in ALAD expression and a change in the cell content of an active ALAD/hemB form. Further study of heme biosynthesis and the role of ALAD/hemB in morphogenesis of basal animals may provide new opportunities for treating pathologies in higher animals.PMID:38062963

Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: O I Kravchuk A D Finoshin K V Mikhailov R H Ziganshin K I Adameyko N G Gornostaev A I Zhurakovskaya V S Mikhailov E I Shagimardanova Yu V Lyupina Source Type: research