Sortilin in biliary epithelial cells promotes ductular reaction and fibrosis during cholestatic injury
This study investigated the interplay between sortilin, IL-6 and LIF in cholestatic injury-induced ductular reaction, morphogenesis of new ducts and fibrosis. Cholestatic injury was induced by bile duct ligation (BDL) in WT and Sort1-/- mice, with or without augmentation of IL-6 or LIF.
Source: American Journal of Pathology - Category: Pathology Authors: Einav Hubel, Anat Neuman, Sigal Fishman, Ortal Schaffer, Noam Erez, Bander Abu Shrkihe, Yuval Shteingard, Tamar Gross, Oren Shibolet, Chen Varol, Isabel Zvibel Tags: Regular Article Source Type: research