Resolvins protect against diabetes ‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO‐1 pathway

In conclusion, Oxidative stress in diabetes results in mucosal barrier dysfunction, contributing to the development of diabetic diarrhea. Resolvins prevent ROS-mediated mucosal injury and protect gut barrier function by intracellula r PI3K/Akt activation and subsequent HO-1 upregulation in intestinal epithelial cells. These actions result in normalizing stool frequency and stool water content in diabetic mice, suggesting that resolvins may be useful in the treatment of diabetic diarrhea.

Source: BioFactors - March 15, 2024 Category: Biochemistry Authors: Ting Yu, Die Chen, Hongyan Qi, Lin Lin, Yurong Tang Tags: RESEARCH ARTICLE Source Type: research