Abcb10 regulates murine hematopoietic stem cell potential and erythroid differentiation

Erythrocytes, produced in the bone marrow (BM) are the most abundantly produced cells within the body (Hatton et al., 2023). Hematopoietic stem cells (HSC) in the BM are essential for life-long hematopoiesis and are the origin of all erythrocytes (Orkin and Zon, 2008). Although physiological HSCs rarely divide and are cell cycle quiescent (Trumpp et al., 2010) (Wilson et al., 2008), their proliferation and multilineage differentiation also substantiates native adult hematopoiesis (Morcos et al., 2020) (S äwen et al., 2018).
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research