Neural mechanisms of the temporal response of cortical neurons to intracortical microstimulation

Intracortical microstimulation (ICMS) is used to map neuronal circuitry in the brain and restore lost sensory function, including vision, hearing, and somatosensation. The temporal response of cortical neurons to single pulse ICMS is remarkably stereotyped and comprises short latency excitation followed by prolonged inhibition and, in some cases, rebound excitation. However, the neural origin of the different response components to ICMS are poorly understood, and the interactions between the three response components during trains of ICMS pulses remains unclear.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 14, 2024 Category: Neurology Authors: Karthik Kumaravelu, Warren M. Grill Source Type: research