TGF- β1-Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis Through Transcriptionally Upregulating PD-L1 and CXCL12

We elucidated that SOX18 mediated by the TGF- β1-p-Smad2/3 axis shaped the immunosuppressive microenvironment. CXCR4 inhibitor AMD3100 or TGFβR1 inhibitor Vactosertib may boost anti-PD-L1 efficacy and represent novel combinational strategies.

Source: Gastroenterology - February 26, 2024 Category: Gastroenterology Authors: Jie Chen, Weibo Feng, Mengyu Sun, Wenjie Huang, Guodong Wang, Xilang Chen, Yue Yin, Xiaoping Chen, Bixiang Zhang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia Tags: Basic and Translational - Liver Source Type: research