A novel method to quantify fibrin-fibrin and fibrin- α < sub > 2 < /sub > AP cross-links in thrombi formed from human trauma patient plasma

CONCLUSIONS: We have developed a novel method that allows us to quantify fibrin cross-links in trauma patients who have received TXA, providing an indirect measure of fibrinolytic resistance. Using this novel approach we have avoided the effect of TXA and shown that cryo increases fibrin-fibrin and fibrin-α2AP cross-linking when compared to Fg-C, highlighting the importance of FXIII in clot formation and stability in trauma patients.PMID:38462220 | DOI:10.1016/j.jtha.2024.03.001

Source: Thrombosis and Haemostasis - March 10, 2024 Category: Hematology Authors: Gael B Morrow Sarah Flannery Philip D Charles Raphael Heilig Timea Feller Zoe McQuilten Elizabeth Wake Robert A S Ariens James Winearls Nicola J Mutch Roman Fischer Mike A Laffan Nicola Curry Source Type: research