Depletion of Ppp6c in hematopoietic and vascular endothelial cells causes embryonic lethality and decreased hematopoietic potential

Protein phosphatase 6 (PP6) is a Ser/Thr protein phosphatase composed of three subunits: the catalytic subunit Ppp6c and the regulatory subunits Ankrds and SAPS [1]. The diverse phenotypes observed following siRNA-based knockdown of Ppp6c in cultured mammalian cells suggest that PP6 plays roles in cell growth and DNA repair [2-4]. There is also evidence that PP6 regulates NF- κB signaling [5] and mitogen-activated protein kinases (MAPKs) [6, 7] and inactivates TAK1 [8]. Studies in flies indicate that depletion of PpV, a homolog of Ppp6c, results in a cell growth defect [9], suggesting that Ppp6c promotes cell growth.

Source: Experimental Hematology - March 13, 2024 Category: Hematology Authors: Ayumi Kondo, Hirokazu Tanaka, Shinya Rai, Hiroshi Shima, Itaru Matsumura, Toshio Watanabe Tags: Article Source Type: research