APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward A β, through P2RY12

Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues associated with damage. Aging and APOE4 genotype are the strong...

Source: Molecular Neurodegeneration - March 11, 2024 Category: Neurology Authors: Jordy Sepulveda, Jennifer Yejean Kim, Joseph Binder, Stefano Vicini and G. William Rebeck Tags: Research article Source Type: research