Efficacy of metamizole to prevent kidney injury after renal-ischaemic reperfusion injury in Wistar rats

CONCLUSION: Metamizole 100 mg/kgBW can reduce IL-18 and MPO levels in RIRI, giving more optimal results without affecting NGAL levels. Metamizole administration can reduce cumulative EGTI scores in RIRI, both at doses of 100 mg/kgBW and 200 mg/kgBW. This study shows that Metamizole can be used to prevent kidney injury caused by RIRI. IL-18 and MPO can be biomarkers in predicting kidney injury in RIRI.PMID:38463114 | PMC:PMC10923394 | DOI:10.1097/MS9.0000000000001694

Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Dhirajaya Dharma Kadar Syah Mirsya Warli Kiking Ritarwan Muhammad Ichwan Jufriady Ismi Erjan Fikri Juliandi Harahap Ibnu Alferraly Source Type: research