The role of Sirtuin 1 in regulation of fibrotic genes expression in pre-adipocytes

ConclusionThis study highlights that down-regulation ofSirt1 might be a predisposing factor in the emergence of adipose tissue fibrosis by enhancing the expression of extracellular matrix (ECM) components. Activation ofSirt1, similar to suppressing ofHif-1 α in pre-adipocytes may be a beneficial approach for attenuating fibrotic gene expression.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research