SPRY1 deficiency in keratinocytes induces follicular melanocyte stem cells migration to epidermis through p53/SCF/C-KIT signaling

The function and survival of melanocytes is regulated by an elaborate network of paracrine factors synthesized mainly by epidermal keratinocytes. Keratinocytes and melanocytes respond to UV exposure by eliciting a tanning response. However, how keratinocytes and melanocytes interact in the absence of UV exposure is unknown. Here, we demonstrate that after SPRY1 knockout in epidermal keratinocytes, melanocyte stem cells (McSCs) in the hair follicle exit the niche without depleting the pool of these cells.

Source: Journal of Investigative Dermatology - March 8, 2024 Category: Dermatology Authors: Ying-Zhe Cui, Fan Xu, Yuan Zhou, Zhao-Yuan Wang, Xing-Yu Yang, Ni-Chang Fu, Xi-Bei Chen, Yu-Xin Zheng, Xue-Yan Chen, Li-Ran Ye, Ying-Ying Li, Xiao-Yong Man Tags: Original Article Source Type: research