Degrade to stay healthy —Proteolytic interplay during inflammation

by Christian M ünz Proteasomes and autophagy constitute the 2 main proteolytic machineries for cytoplasmic content. A new study in PLOS Biology now demonstrates that autophagy stimulation alters proteasome composition, degrading hyperactive immunoproteasomes and thereby limiting inflammation. Proteasomes and autophagy constitute the two main proteolytic machineries for cytoplasmic content. This Primer explores a new study in PLOS Biology which demonstrates that autophagy stimulation alters proteasome composition, degrading hyperactive immunoproteasomes and thereby limiting inflammation.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002548

Source: PLoS Biology: Archived Table of Contents - March 7, 2024 Category: Biology Authors: Christian M ünz Source Type: research

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