Indolent growth of low ‑grade myofibroblastic sarcoma of the knee with the resemblance of a benign lesion: A case report

Oncol Lett. 2024 Feb 19;27(4):163. doi: 10.3892/ol.2024.14296. eCollection 2024 Apr.ABSTRACTLow-grade myofibroblastic sarcoma (LGMS) is a rare soft-tissue malignant neoplasm originating from the stromal cells that is predominantly comprised of atypical myofibroblasts. The present study reports the case of a patient with low-grade myofibroblastic sarcoma in the soft tissue of the knee. The patient exhibited a soft, painless mass on the medial side of the left knee. During surgery, a yellow-white mass above the posterior margin of the sartorius muscle was identified. This mass, which was irregular and adherent to surrounding tissues, had a blurry boundary, indicative of invasive growth. The morphology of the mass significantly differed from conventional lipomas and was lacking typical features. Immunohistochemical staining confirmed the diagnosis of a malignant LGMS. The patient experienced no recurrence over 1 year of follow-up and reported complete recovery of knee range of motion. The present study suggests that an incisional biopsy may be performed if LGMS is suspected based on patient symptoms and imaging results. In addition, long-term follow-up is crucial for the timely detection and management of any recurrence, playing a key role in the patient's ongoing care and treatment.PMID:38426155 | PMC:PMC10902747 | DOI:10.3892/ol.2024.14296
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research